EXPERIMENTAL EVALUATION OF PREVENTIVE AND THERAPEUTIC POTENTIALS OF LYSOZYME

被引：51

作者：

DAS, S

BANERJEE, S

GUPTA, JD

机构：

[1] Department of Experimental Leukaemia, Chittaranjan National Cancer Instit

来源：

CHEMOTHERAPY | 1992年 / 38卷 / 05期

关键词：

SARCOMA-180; EHRLICHS CARCINOMA; DALTONS LYMPHOMA; LYSOZYME; CHEMOTHERAPY; CHEMOPREVENTION;

D O I：

10.1159/000239025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Therapeutic efficacy and preventive role of egg white lysozyme was evaluated in three types of murine ascitic tumours, namely sarcoma 180, Ehrlich's carcinoma, and Dalton's lymphoma. Lysozyme treatment produced regression of tumour growth and improved the life expectancy of the host. Growth of tumour cells treated in vitro with lysozyme prior to transplantation was also affected. In addition, lysozyme was found to have a preventive effect when administered to normal mice. The antitumour activity, therapeutic and preventive, of lysozyme seems to be due to its action on the tumour cell surface as well as on the host-mediated immune response.

引用

页码：350 / 357

页数：8

共 27 条

[1] FINE SPECIFICITY OF REGULATORY T-CELLS .2. SUPPRESSOR AND HELPER T-CELLS ARE INDUCED BY DIFFERENT REGIONS OF HEN EGG-WHITE LYSOZYME IN A GENETICALLY NONRESPONDER MOUSE STRAIN [J].