EFFECTS OF MORPHINE AND D-ALA2-D-LEU5-ENKEPHALIN IN THE SEIZURE-SUSCEPTIBLE EL-MOUSE

被引:20
作者
KOIDE, S
ONISHI, H
YAMAGAMI, S
KAWAKITA, Y
机构
[1] Department of Neuropsychiatry, Osaka City University Medical School, Osaka
关键词
EL-MOUSE; MORPHINE; ENKEPHALINS; SEIZURE; EPILEPSY;
D O I
10.1007/BF00969012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Opioid agonists were used to investigate the modulation of seizures in the seizure-susceptible El mouse. Morphine and D-Ala2-D-Leu5-enkephalin (DADLE) were injected subcutaneously or intracisternally as prototypic agonists for mu and delta-opioid receptors. Systemic or intracisternal injection of both morphine and DADLE decreased the incidence of seizures and the seizure score in El mice in a dose-dependent manner. The anticonvulsant effects of morphine and DADLE were reversed by naloxone (2 mg/kg, s.c.). This implies that opioid agonists have anticonvulsant properties which are mediated by mu and delta-opioid receptors. In conclusion, a deficit in endogenous opioid peptides, which act as anticonvulsants may play a significant role in the etiology or pathophysiology of seizures in the El mouse.
引用
收藏
页码:779 / 783
页数:5
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