THE INHIBITION BY INDOLEAMINES (TRYPTAMINE AND SEROTONIN) OF OCULAR SEROTONIN-N-ACETYLTRANSFERASE FROM RANA-PEREZI IS TEMPERATURE-DEPENDENT

被引：6

作者：

ALONSOGOMEZ, AL ^{[1
]}

ALONSOBEDATE, M ^{[1
]}

DELGADO, MJ ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,FAC BIOL,DEPT BIOL ANIM FISIOL ANIM 2,E-28040 MADRID,SPAIN

来源：

NEUROSCIENCE LETTERS | 1993年 / 155卷 / 01期

关键词：

SEROTONIN N-ACETYLTRANSFERASE; RETINA; FROG; ENZYME KINETICS; TEMPERATURE; INHIBITION BY SUBSTRATE;

D O I：

10.1016/0304-3940(93)90667-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization from R. perezi retina. NAT shows an inhibition by high substrate (serotonin) concentration, which is temperature-dependent. NAT follows the Michaelis-Menten equation at low temperature, whereas at high temperatures (>10-degrees-C) an inhibition by serotonin is observed. This inhibition of NAT activity by serotonin could act as an amplification mechanism to increase daily melatonin rhythm amplitude in the retina of ectotherms.

引用

页码：33 / 36

页数：4

共 18 条

[1] THERMAL SENSITIVITY AND EFFECT OF TEMPERATURE-ACCLIMATION ON OCULAR SEROTONIN NORMAL-ACETYLTRANSFERASE ACTIVITY IN RANA-PEREZI [J].

ALONSOGOMEZ, AL ;

ALONSOBEDATE, M ;

DELGADO, MJ .

NEUROSCIENCE LETTERS, 1992, 142 (02) :187-190

[2] CHARACTERIZATION OF SEROTONIN N-ACETYLTRANSFERASE IN THE LATERAL EYE OF THE GREEN FROG RANA-PEREZI - PROTECTIVE ACTION OF EGTA [J].

ALONSOGOMEZ, AL ;

GANCEDO, B ;

ALONSOBEDATE, M ;

AGAPITO, MT ;

DELGADO, MJ .

JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) :587-592

[3] CIRCADIAN-RHYTHMS OF PINEAL FUNCTION IN RATS [J].

BINKLEY, SA .

ENDOCRINE REVIEWS, 1983, 4 (03) :255-270

[4] EFFECT OF ENVIRONMENTAL-TEMPERATURE AND PHOTOPERIOD ON THE MELATONIN LEVELS IN THE PINEAL, LATERAL EYE, AND PLASMA OF THE FROG, RANA-PEREZI - IMPORTANCE OF OCULAR MELATONIN [J].

DELGADO, MJ ;

VIVIENROELS, B .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1989, 75 (01) :46-53

[5]

Dixon M., 1979, ENZYMES, P47

[6]

DUGLEBY RG, 1981, ANAL BIOCHEM, V110, P9

[7] INVOLVEMENT OF CALCIUM IN THE REGULATION OF SEROTONIN N-ACETYLTRANSFERASE IN RETINA [J].

IUVONE, PM ;

BESHARSE, JC .

JOURNAL OF NEUROCHEMISTRY, 1986, 46 (01) :82-88

[8] INHIBITION OF DAY TIME, BUT NOT ISOPROTERENOL-STIMULATED PINEAL N-ACETYLTRANSFERASE ACTIVITY BY AN UNIDENTIFIED PINEAL COMPOUND [J].

KHOORY, R ;

SCHLOOT, W .

JOURNAL OF NEURAL TRANSMISSION, 1986, 66 (3-4) :281-289

[9]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[10] CIRCADIAN-RHYTHMS IN SEROTONIN, NOREPINEPHRINE, AND EPINEPHRINE CONTENTS OF THE PINEAL PARAPHYSEAL COMPLEX OF THE SOFT-SHELLED TURTLE (LISSEMYS-PUNCTATA-PUNCTATA) [J].

MAHAPATRA, MS ;

MAHATA, SK ;

MAITI, BR .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1986, 64 (02) :246-249

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