PLASMA AND RED-CELL GLYCOLIPID PATTERNS OF LE(A+B+) AND LE(A+B-) POLYNESIANS AS FURTHER EVIDENCE OF THE WEAK SECRETOR GENE SE(W)

被引:23
作者
HENRY, SM
WOODFIELD, DG
SAMUELSSON, BE
ORIOL, R
机构
[1] UNIV AUCKLAND, DEPT BIOCHEM, AUCKLAND, NEW ZEALAND
[2] GOTHENBURG UNIV, DEPT MED BIOCHEM, S-41124 GOTHENBURG, SWEDEN
[3] INSERM, U178, F-94800 VILLEJUIF, FRANCE
关键词
D O I
10.1111/j.1423-0410.1993.tb04527.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Monoclonal antibodies a nd thin-layer chromatography were used to study the unusual erythrocyte Lewis phenotypes found in healthy Polynesians. A single monoclonal anti-Le(b) reagent 073 (clone LM129) was found which could detect Le(b) antigen on the Polynesian erythrocytes of samples that were unreactive with various polyclonal and monoclonal anti-Le(b) reagents. Glycolipid fractions prepared from the plasma and erythrocytes of selected Polynesian samples of red-cell Le(a-b-), Le(a+b-) and Le(a+b+) phenotypes were found to have Le(b) glycolipids. The Le(b) antigen in some individuals is so weakly expressed that it is undetectable by routine erythrocyte phenotyping. Unusually large glycolipids bearing the Le(b) epitope were also found in some Polynesian samples, although the contribution of these novel glycolipids to phenotyping is unclear. The inability to detect Le(b) by routine methods and the presence of novel structures can be partially explained in terms of the presence of a weak secretor gene Se(w).
引用
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页码:62 / 69
页数:8
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