ENHANCEMENT OF MORPHINE ANALGESIA BY THE GABA(B) AGONIST BACLOFEN

被引：87

作者：

GORDON, NC

GEAR, RW

HELLER, PH

PAUL, S

MIASKOWSKI, C

LEVINE, JD

机构：

[1] UNIV CALIF SAN FRANCISCO, DEPT ORAL & MAXILLOFACIAL SURG, DIV RHEUMATOL, SAN FRANCISCO, CA 94143 USA

[2] UNIV CALIF SAN FRANCISCO, GRAD PROGRAM ORAL BIOL, SAN FRANCISCO, CA 94143 USA

[3] UNIV CALIF SAN FRANCISCO, GRAD PROGRAM NEUROSCI, SAN FRANCISCO, CA 94143 USA

[4] UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL NURSING, SAN FRANCISCO, CA 94143 USA

[5] UNIV CALIF SAN FRANCISCO, DEPT EPIDEMIOL & BIOSTAT, SAN FRANCISCO, CA 94143 USA

[6] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA

[7] UNIV CALIF SAN FRANCISCO, DEPT ANAT, SAN FRANCISCO, CA 94143 USA

[8] KAISER FDN HOSP, HAYWARD, CA 94545 USA

来源：

NEUROSCIENCE | 1995年 / 69卷 / 02期

关键词：

GENDER; PENTAZOCINE; KAPPA-OPIOID; MU-OPIOID; DENTAL PAIN;

D O I：

10.1016/0306-4522(95)00335-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Opioid-GABAergic interactions for the treatment of post-operative pain were investigated in two double-blind, placebo-controlled experiments. We first studied the effect of pre-operatively administered baclofen, a GABA(B) receptor agonist, on the analgesia produced by intravenously administered morphine, a predominantly mu-opioid analgesic. In a separate trial, we studied the effect of baclofen on the analgesia produced by pentazocine, a predominantly kappa-opioid analgesic. While baclofen alone did not affect the level of post-operative pain, morphine analgesia was significantly enhanced by baclofen compared to placebo. In contrast, baclofen did not affect the level of pentazocine analgesia: however, females receiving pentazocine showed significantly greater analgesia than males.

引用

页码：345 / 349

页数：5

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