NIFEDIPINE ENHANCES THE CARDIAC TOXICITY OF MAGNESIUM-SULFATE IN THE ISOLATED PERFUSED SPRAGUE-DAWLEY RAT-HEART

被引：16

作者：

THORP, JM ^{[1
]}

SPIELMAN, FJ ^{[1
]}

VALEA, FA ^{[1
]}

PAYNE, FG ^{[1
]}

MUELLER, RA ^{[1
]}

CEFALO, RC ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT ANESTHESIOL,CHAPEL HILL,NC 27599

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 163卷 / 02期

关键词：

magnesium sulfate; Nifedipine; tocolysis;

D O I：

10.1016/0002-9378(90)91218-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Magnesium sulfate is commonly used in tocolytic regimens and as prophylaxis against seizures. Nifedipine may be used simultaneously in either situation. With the isolated perfused rat heart model (Sprague-Dawley rats), we investigated the effects of these agents on cardiac function. Whereas each agent alone depressed cardiac performance, the two drugs together had maximal depressive effects on the heart. © 1990.

引用

页码：655 / 656

页数：2

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