CLINICAL-EVALUATION OF ORAL FLUID SAMPLES FOR DIAGNOSIS OF VIRAL-HEPATITIS

被引：66

作者：

THIEME, T ^{[1
]}

YOSHIHARA, P ^{[1
]}

PIACENTINI, S ^{[1
]}

BELLER, M ^{[1
]}

机构：

[1] WASHINGTON CTY DEPT HLTH & HUMAN SERV,HILLSBORO,OR 97124

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1992年 / 30卷 / 05期

关键词：

D O I：

10.1128/JCM.30.5.1076-1079.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oral fluid samples were compared with serum samples as a specimen source for hepatitis A, B, and C virus markers. Oral fluid was obtained with a treated absorbent pad and tested by using existing commercial enzyme immunoassays with only minor modifications. Compared with serum sampling the sensitivity and specificity of oral sampling were 100% (51 of 51 samples) and 98% (46 of 47 samples) for hepatitis A virus immunoglobulin M, 100% (29 of 29 samples) and 100% (29 of 29 samples) for hepatitis B virus surface antigen, and 100% (13 of 13 samples) and 100% (13 of 13 samples) for hepatitis C virus antibody, respectively. The decline of hepatitis A virus immunoglobulin M in oral samples was parallel to, though somewhat more rapid than, that of hepatitis A virus immunoglobulin M in serum samples. It is proposed that oral sampling represents a safer and more convenient procedure for reliable hepatitis virus testing than blood sampling and that it has wide application in patient and outbreak management.

引用

页码：1076 / 1079

页数：4

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