CAPSAICIN ENHANCES ALLERGIC CONTACT-DERMATITIS IN THE GUINEA-PIG

被引：17

作者：

WALLENGREN, J

EKMAN, R

MOLLER, H

机构：

[1] UNIV LUND,DEPT DERMATOL,S-22101 LUND,SWEDEN

[2] UNIV LUND,DEPT EXPTL RES,S-22101 LUND,SWEDEN

[3] UNIV LUND,DEPT NEUROCHEM,S-22101 LUND,SWEDEN

来源：

CONTACT DERMATITIS | 1991年 / 24卷 / 01期

关键词：

ALLERGIC CONTACT DERMATITIS; SUBSTANCE-P; CAPSAICIN; GUINEA PIG SENSITIZATION; DINITROCHLOROBENZENE; ENHANCING EFFECT;

D O I：

10.1111/j.1600-0536.1991.tb01626.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously on the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well as by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization. In comparison with controls, the contact dermatitis was enhanced in both groups of animals treated with capsaicin.

引用

页码：30 / 34

页数：5

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