HUMAN RECOMBINANT GRANULOCYTE COLONY-STIMULATING FACTOR FOR THE TREATMENT OF AUTOIMMUNE NEUTROPENIA

被引：20

作者：

TAKAHASHI, K

TANIGUCHI, S

AKASHI, K

FUJIMOTO, K

SIBUYA, T

ISHIBASHI, H

HARADA, M

NIHO, Y

机构：

[1] First Department of Internal Medicine, Kyushu University, Fukuoka

来源：

ACTA HAEMATOLOGICA | 1991年 / 86卷 / 02期

关键词：

AUTOIMMUNE NEUTROPENIA; GRANULOCYTE COLONY-STIMULATING FACTOR;

D O I：

10.1159/000204811

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have recently treated a case of autoimmune neutropenia in a 57-year-old male. Because neutropenia persisted despite the administration of prednisolone for 30 days, daily subcutaneous injection of human recombinant granulocyte colony-stimulating factor (rhG-CSF) at a dosage of 100-mu-g was started. Neutrophil count increased gradually and reached a plateau of 5,000/mu-l by day 25 after administration of rhG-CSF. This observation suggests that rhG-CSF is effective for the treatment of autoimmune neutropenia.

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收藏

页码：95 / 98

页数：4

相关论文

共 8 条

[1] AUTOIMMUNE NEUTROPENIA [J].

BOXER, LA ;

GREENBERG, MS ;

BOXER, GJ ;

STOSSEL, TP .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (15) :748-753

[2] TREATMENT OF CYCLIC NEUTROPENIA WITH GRANULOCYTE COLONY-STIMULATING FACTOR [J].

HAMMOND, WP ;

PRICE, TH ;

SOUZA, LM ;

DALE, DC .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (20) :1306-1311

[3] EFFECTS OF HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR IN A PATIENT WITH IDIOPATHIC NEUTROPENIA [J].

JAKUBOWSKI, AA ;

SOUZA, L ;

KELLY, F ;

FAIN, K ;

BUDMAN, D ;

CLARKSON, B ;

BONILLA, MA ;

MOORE, MAS ;

GABRILOVE, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (01) :38-42

[4]

KODO H, 1988, LANCET, V2, P38

[5] EFFECT OF GRANULOCYTE COLONY STIMULATING FACTOR ON NEUTROPENIA INDUCED BY CYTO-TOXIC CHEMOTHERAPY [J].

MORSTYN, G ;

SOUZA, LM ;

KEECH, J ;

SHERIDAN, W ;

CAMPBELL, L ;

ALTON, NK ;

GREEN, M ;

METCALF, D ;

FOX, R .

LANCET, 1988, 1 (8587) :667-672

[6]

POLLACK S, 1982, NEW ENGL J MED, V307, P253

[7] RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR - EFFECTS ON NORMAL AND LEUKEMIC MYELOID CELLS [J].

SOUZA, LM ;

BOONE, TC ;

GABRILOVE, J ;

LAI, PH ;

ZSEBO, KM ;

MURDOCK, DC ;

CHAZIN, VR ;

BRUSZEWSKI, J ;

LU, H ;

CHEN, KK ;

BARENDT, J ;

PLATZER, E ;

MOORE, MAS ;

MERTELSMANN, R ;

WELTE, K .

SCIENCE, 1986, 232 (4746) :61-65

[8] RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR - MOLECULAR AND BIOLOGICAL CHARACTERIZATION [J].

ZSEBO, KM ;

COHEN, AM ;

MURDOCK, DC ;

BOONE, TC ;

INOUE, H ;

CHAZIN, VR ;

HINES, D ;

SOUZA, LM .

IMMUNOBIOLOGY, 1986, 172 (3-5) :175-184