SYNTHESIS OF 2-SUBSTITUTED BENZOTHIAZOLES FROM 2-FLUOROPHENYLISOTHIOCYANATE

被引：21

作者：

ARES, JJ

机构：

[1] Department of Chemistry, Worcester Polytechnic Institute, Worcester

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 05期

关键词：

D O I：

10.1080/00397919108020829

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 2-fluorophenylisothiocyanate with a Grignard reagent, followed by base-induced cyclization of the resulting thioamide, provides a convenient method of synthesizing 2-substituted benzothiazoles. Best results are obtained upon isolation and purification of the intermediate thioamide, but a direct one-pot isothiocyanate-to-benzothiazole transformation has also been achieved.

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页码：625 / 633

页数：9

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