CONCENTRATION OF AZITHROMYCIN IN HUMAN PROSTATIC TISSUE

被引：36

作者：

FOULDS, G

MADSEN, P

COX, C

SHEPARD, R

JOHNSON, R

机构：

[1] VET ADM MED CTR,UROL SECT,MADISON,WI 53705

[2] UNIV TENNESSEE,CTR HLTH SCI,COLL MED,DEPT MICROBIOL & GENET,MEMPHIS,TN 38163

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1991年 / 10卷 / 10期

关键词：

D O I：

10.1007/BF01975845

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Prostatic tissue was obtained from 36 patients at two study locations and assayed for azithromycin by HPLC or bioassay. The mean concentration of azithromycin in human prostatic tissue (2.54-mu-g/ml) 14 h after 500 mg oral dosing (two 250 mg doses 12 h apart) was much greater than plasma concentrations (less-than-or-equal-to 0.1-mu-g/ml). Azithromycin was slowly eliminated from prostatic tissue (half-life 60 h) and a mean concentration of 0.62-mu-g/ml remained 137 h after dosing.

引用

页码：868 / 871

页数：4

共 13 条

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