LEAVING GROUP SPECIFICITY IN CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF PEPTIDES - STEREOCHEMICAL INTERPRETATION

被引：148

作者：

FERSHT, AR ^{[1
]}

BLOW, DM ^{[1
]}

FASTREZ, J ^{[1
]}

机构：

[1] MRC,LAB MOLEC BIOL,CAMBRIDGE,ENGLAND

来源：

BIOCHEMISTRY | 1973年 / 12卷 / 11期

关键词：

D O I：

10.1021/bi00735a002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2035 / 2041

页数：7

共 24 条

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[3] ON INTERACTION OF ACTIVE SITE OF ALPHA-CHYMOTRYPSIN WITH CHROMOPHORES - PROFLAVIN BINDING AND ENZYME CONFORMATION DURING CATALYSIS
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[4] MECHANISM OF AMINOLYSIS OF METHYL FORMATE
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[5] MODEL FOR ASSOCIATION OF BOVINE PANCREATIC TRYPSIN-INHIBITOR WITH CHYMOTRYPSIN AND TRYPSIN
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[J]. JOURNAL OF MOLECULAR BIOLOGY, 1972, 69 (01) : 137 - +
[6] CAPLOW M, 1964, J BIOL CHEM, V239, P1640
[7] MECHANISM OF CHYMOTRYPSIN - STRUCTURE, REACTIVITY, AND NONPRODUCTIVE BINDING RELATIONSHIPS
FASTREZ, J
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[J]. BIOCHEMISTRY, 1973, 12 (06) : 1067 - 1074
[8] DEMONSTRATION OF ACYL-ENZYME MECHANISM FOR HYDROLYSIS OF PEPTIDES AND ANILIDES BY CHYMOTRYPSIN
FASTREZ, J
FERSHT, AR
[J]. BIOCHEMISTRY, 1973, 12 (11) : 2025 - 2034
[9] ACYL-TRANSFER REACTIONS OF AMIDES AND ESTERS WITH ALCOHOLS AND THIOLS - REFERENCE SYSTEM FOR SERINE AND CYSTEINE PROTEINASES - CONCERNING N PROTONATION OF AMIDES AND AMIDE-IMIDATE EQUILIBRIA
FERSHT, AR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (14) : 3504 - &
[10] FREE ENERGIES OF HYDROLYSIS OF AMIDES AND PEPTIDES IN AQUEOUS SOLUTION AT 25 DEGREES
FERSHT, AR
REQUENA, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (14) : 3499 - &

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