FACTORS ASSOCIATED WITH THE DEVELOPMENT OF PNEUMOCYSTIS-CARINII PNEUMONIA IN 5,025 EUROPEAN PATIENTS WITH AIDS

被引：25

作者：

LUNDGREN, JD

BARTON, SE

LAZZARIN, A

DANNER, S

GOEBEL, FD

PEHRSON, P

MULCAHY, F

KOSMIDIS, J

PEDERSEN, C

PHILLIPS, AN

CLUMECK, N

DEWIT, S

SOMMEREIJNS, B

NIELSEN, JO

LUNDGREN, J

NIELSEN, T

JENSEN, G

SKINHOJ, P

BENTSEN, K

GERSTOFT, J

MELBYE, M

RANKI, A

VALLE, SL

KATLAMA, C

BERLUREAU, P

DIETRICH, M

SCHWANDER, S

PAPADOPOULOS, A

BANHEGYI, D

YUST, I

BENISHAI, Z

BENTWICH, Z

SACKS, T

MAAYAN, S

VELLA, S

CHIESI, A

ANCARANI, F

SCALISE, G

BERTAGGIA, A

FRANCAVILLA, E

CALONGHI, G

CARGNEL, A

ARLOTTI, M

CIAMMARUGHI, R

COLOMBA, A

DELALLA, F

FASSIO, P

FERLINI, A

FIACCADORI, F

PASETTI, G

机构：

[1] ST STEPHENS CLIN, LONDON, ENGLAND

[2] UCL, SCH MED, LONDON W1N 8AA, ENGLAND

[3] UNIV MILAN, MILAN, ITALY

[4] ACAD MED CTR, AMSTERDAM, NETHERLANDS

[5] UNIV MUNICH, MED POLIKLIN, W-8000 MUNICH, GERMANY

[6] HUDDINGE SJUKHUS, HUDDINGE, SWEDEN

[7] ST JAMES HOSP, DUBLIN 8, IRELAND

[8] GEN HOSP ATHENS, ATHENS, GREECE

[9] ST PIERRE HOSP, BRUSSELS, BELGIUM

[10] FREDERIKSBERG UNIV HOSP, FREDERIKSBERG, DENMARK

[11] RIGSHOSP, DK-2100 COPENHAGEN, DENMARK

[12] HELSINKI UNIV, CENT HOSP, HELSINKI, FINLAND

[13] HOSP PITIE SALPETRIERE, PARIS, FRANCE

[14] BERNHARD NOCHT INST TROP MED, HAMBURG, GERMANY

[15] FIRST IKA HOSP, ATHENS, GREECE

[16] POSTGRAD MED UNIV, H-1389 BUDAPEST, HUNGARY

[17] ICHILOV HOSP, IL-64239 TEL AVIV, ISRAEL

[18] RAMBAM MED CTR, HAIFA, ISRAEL

[19] KAPLAN HOSP, IL-76100 REHOVOT, ISRAEL

[20] HADASSAH UNIV HOSP, IL-91120 JERUSALEM, ISRAEL

[21] IST SUPER SANITA, I-00161 ROME, ITALY

[22] UNIV ANCONA, ANCONA, ITALY

[23] OSPED CIVILE, PADUA, ITALY

[24] ARCISPEDALE SANTA MARIA NUOVA, REGGIONELL EMILIA, ITALY

[25] OSPITALE SACCO, MILAN, ITALY

[26] OSPITALE INFERMI RIMINI, RIMINI, ITALY

[27] OSPITALE CASA SOLE, PALERMO, ITALY

[28] OSPITALE CIVILE, VICENZA, ITALY

[29] OORR BERGAMO, BERGAMO, ITALY

[30] OSPITALE INFERMI FAENZA, FAENZA, ITALY

[31] OSPITALE RIUNITI, PARMA, ITALY

[32] OSPITALE NIGUARDA GRANDA, MILAN, ITALY

[33] OSPITALE AMEDEO SAVOIA, TURIN, ITALY

[34] OSPITALE L SACCO, MILAN, ITALY

[35] OSPITALE SANTA ANDREA, LA SPEZIA, ITALY

[36] PATOL MED UNIV CATANIA, CATANIA, ITALY

[37] UNIV CATTOLICA SACRO CUORE, ROME, ITALY

[38] UNIV SASSARI, I-07100 SASSARI, ITALY

[39] MONTELUCE POLICLIN, PERUGIA, ITALY

[40] OSPITALE GALLIERA, GENOA, ITALY

[41] OSPITALE SANTA MARIA CROCI, RAVENNA, ITALY

[42] OSPITALE MAGGIORE, NOVARA, ITALY

[43] OSPITALE SANTA MARIA MADDALENA, TRIESTE, ITALY

[44] OSPITALE SANTA MARIA MADDALENA, TURIN, ITALY

[45] CTR HOSP, LUXEMBOURG, LUXEMBOURG

[46] UNIV AMSTERDAM, ACAD ZIEKENHUIS, AMSTERDAM, NETHERLANDS

[47] HOSP SANTA MARIA, LISBON, PORTUGAL

[48] HOSP CURRY CABRAL, LISBON, PORTUGAL

[49] INST CARLOS III, MADRID, SPAIN

[50] HOSP GERMANS TRIAS & PUJOL, BARCELONA, SPAIN

来源：

CLINICAL INFECTIOUS DISEASES | 1995年 / 21卷 / 01期

关键词：

D O I：

10.1093/clinids/21.1.106

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study examined the factors associated with the development of a first episode of Pneumacystis carinii pneumonia (PCP) in 5,025 patients with AIDS, including 1,976 patients with primary PCP at the time of AIDS diagnosis and 635 with primary PCP occurring subsequently. Compared with untreated patients, patients treated with zidovudine were at similar risk of developing PCP during the first year of therapy but were at greater risk after longer intervals of treatment. The following factors were associated with an increased risk of PCP (either at the time of AIDS diagnosis or thereafter): lack of primary PCP prophylaxis, male homosexuality/bisexuality, diagnosis of AIDS in northern Europe, and CD4 cell count below 200 x 10(6)/L at the time of AIDS diagnosis. Patients with severe weight loss had a 60% higher risk of developing PCP during follow-up than those without such weight loss. Thus, the occurrence of PCP depended on geographic location, mode of acquisition of human immunodeficiency virus and AIDS, degree of immunodeficiency, and use of various treatment regimens.

引用

页码：106 / 113

页数：8

共 27 条

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