IDENTIFICATION OF A NOVEL PLATELET-DERIVED NEUTROPHIL-CHEMOTACTIC POLYPEPTIDE WITH STRUCTURAL HOMOLOGY TO PLATELET-FACTOR-4

被引：11

作者：

SCHRODER, JM ^{[1
]}

STICHERLING, M ^{[1
]}

PERSOON, NLM ^{[1
]}

CHRISTOPHERS, E ^{[1
]}

机构：

[1] ROYAL GIST BROCADES NV,DELFT,NETHERLANDS

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90760-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel protein, NAP-4, could be isolated from human platelet lysates. NAP-4 preparations induced chemotaxis of human neutrophils with an ED50 near 400 ng/ml. Purification by anti NAP-1 IL-8 affinity chromatography and reversed phase HPLC revealed a single peak showing a single line upon SDS-PAGE corresponding to a Mr of 8000. NH2-terminal sequence analysis indicated an unique sequence showing strong homology to human platelet factor 4 and weak homology to tumor necrosis factor α as well. The most interesting finding is the absence of the first two cysteins, known to be strongly conserved in members of the family of platelet-factor 4-like host defense cytokines. © 1990.

引用

页码：898 / 904

页数：7

共 17 条

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