EVALUATION OF CYTOTOXIC AGENTS IN HUMAN COLONIC TUMOR XENOGRAFTS AND MOUSE GASTRO-INTESTINAL TISSUES USING A THYMIDINE-H-3 FRACTIONAL INCORPORATION ASSAY

被引：13

作者：

HOUGHTON, JA ^{[1
]}

HOUGHTON, PJ ^{[1
]}

机构：

[1] INST CANC RES,DEPT RADIOPHARMACOL,DIV BIOPHYS,SUTTON SM2 5PX,SURREY,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1979年 / 15卷 / 05期

关键词：

D O I：

10.1016/0014-2964(79)90151-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug induced changes in 3H-thymidine fractional incorporation (TFI) in 4 human colonic xenograft lines and mouse gastrointestinal tissues have been related to the growth inhibition and host toxicity respectively. Using the TFI assay, the combinations of actinomycin D with cyclophosphamide and methyl CCNU with pentamethyl-melamine have been examined. Both combinations showed greater than additive activity against only 1 of the 3 xenograft lines in which they were tested. The TFI assay allows more rapid evaluation of drug activity and is more sensitive than growth delay studies. It also allows quantitative measurement of cytotoxic activity in gastrointestinal tissues after sublethal dose levels. © 1979.

引用

页码：763 / 769

页数：7

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