ISCHEMIA REPERFUSION INJURY AND HISTAMINE-RELEASE IN ISOLATED AND PERFUSED GUINEA-PIG HEART - PHARMACOLOGICAL INTERVENTIONS

被引：24

作者：

MASINI, E ^{[1
]}

BIANCHI, S ^{[1
]}

GAMBASSI, F ^{[1
]}

PALMERANI, B ^{[1
]}

PISTELLI, A ^{[1
]}

CARLOMAGNO, L ^{[1
]}

MANNAIONI, PF ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT ANIM BIOL,I-50134 FLORENCE,ITALY

来源：

AGENTS AND ACTIONS | 1990年 / 30卷 / 1-2期

关键词：

D O I：

10.1007/BF01969037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions. © 1990 Birkhäuser Verlag.

引用

页码：198 / 201

页数：4

共 9 条

[1] CARDIOPROTECTIVE ACTIONS OF HUMAN SUPEROXIDE-DISMUTASE IN 2 REPERFUSION MODELS OF MYOCARDIAL ISCHEMIA IN THE RAT [J].