IMPAIRMENT OF ANTIGEN-PRESENTING CELL-FUNCTION BY ULTRAVIOLET-RADIATION

被引：278

作者：

GREENE, MI ^{[1
]}

SY, MS ^{[1
]}

KRIPKE, M ^{[1
]}

BENACERRAF, B ^{[1
]}

机构：

[1] NCI, FREDERICK CANC RES CTR, FREDERICK, MD 21701 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 12期

关键词：

D O I：

10.1073/pnas.76.12.6591

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

UV light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of UV-treated donors could not induce hapten-specific delayed hypersensitivity responses in UV-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cells from normal mice were able to do so. The failure to induce immunity in UV-treated mice by utilizing UV-treated adherent antigen-presenting cells was associated with the development of antigen-specific suppressor T cells. The implication of these results for UV-induced carcinogenesis is discussed.

引用

页码：6591 / 6595

页数：5

共 29 条

[1]

BACH BA, 1978, J IMMUNOL, V121, P1460

[2] ANTIGENIC REQUIREMENTS FOR TRIGGERING OF CYTOTOXIC T LYMPHOCYTES [J].