TOXICITY AND ACTIVITY OF PURIFIED TRICHOSANTHIN

被引：24

作者：

FERRARI, P

TRABAUD, MA

ROMMAIN, M

MANDINE, E

ZALISZ, R

DESGRANGES, C

SMETS, P

机构：

[1] ROUSSEL UCLAF,CTR RECH IMMUNOL,LABS CASSENNE,F-95521 CERGY,FRANCE

[2] INSERM,U271,F-69008 LYONS,FRANCE

来源：

AIDS | 1991年 / 5卷 / 07期

关键词：

TRICHOSANTHIN; TOXICITY; ACTIVITY; HIV; COLORIMETRIC ASSAY; T-CELLS; AIDS; ANTIBODY;

D O I：

10.1097/00002030-199107000-00011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Trichosanthin was purified from fresh Chinese root tubers of Trichosanthes kirilowii and evaluated for anti-HIV activity. Trichosanthin inhibited syncytium formation between infected H9 cells and uninfected Sup-T1 cells from 0.5 to 4-mu-g/ml. Trichosanthin also inhibited HIV replication in H9 and CEM-SS cells at 1-mu-g/ml, but was toxic for MT-4 cells (HTLV-I-positive), at doses greater than 0.25-mu-g/ml. This new purification procedure confirms the anti-HIV activity of trichosanthin on some cell lines in different biological assays.

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收藏

页码：865 / 870

页数：6

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