EFFECT OF SIMETHICONE ON LACTULOSE-INDUCED H-2 PRODUCTION AND GASTROINTESTINAL SYMPTOMS

被引:21
作者
FRIIS, H
BODE, S
RUMESSEN, JJ
GUDMANDHOYER, E
机构
[1] Department of Gastroenterology and Internal Medicine P, Gentofte University Hospital, Hellerup
关键词
SIMETHICONE; CARBOHYDRATE MALABSORPTION; H-2; EXCRETION;
D O I
10.1159/000200726
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H-2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.
引用
收藏
页码:227 / 230
页数:4
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