AFRICAN SWINE FEVER VIRUS ENCODES A GENE WITH EXTENSIVE HOMOLOGY TO TYPE-II DNA TOPOISOMERASES

被引：24

作者：

BAYLIS, SA

DIXON, LK

VYDELINGUM, S

SMITH, GL

机构：

[1] UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,S PARKS RD,OXFORD OX1 3RE,ENGLAND

[2] AFRC,INST ANIM HLTH,PIRBRIGHT LAB,WOKING GU24 0NF,SURREY,ENGLAND

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1992年 / 228卷 / 03期

关键词：

AFRICAN SWINE FEVER VIRUS; ASFV; DNA TOPOISOMERASE-II; HOMOLOGY; CYTOPLASMIC REPLICATION;

D O I：

10.1016/0022-2836(92)90887-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleotide sequencing of a virulent African swine fever virus (ASFV) isolate (Malawi LIL20/1) identified an open reading frame of 1191 amino acid residues encoding a protein of 134·9 kDa. This gene mapped to the SalI i and j restriction endonuclease fragments of the ASFV genome. The predicted polypeptide was found to share 21·1% identity over a 1077 amino acid region with the human type II DNA topoisomerase. The sequence is compared to other type II DNA topoisomerases and the possible roles in ASFV replication are discussed. © 1992.

引用

页码：1003 / 1010

页数：8

共 57 条

[1] DNA-SEQUENCE OF THE ESCHERICHIA-COLI GYRB GENE - APPLICATION OF A NEW SEQUENCING STRATEGY
ADACHI, T
MIZUUCHI, M
ROBINSON, EA
APPELLA, E
ODEA, MH
GELLERT, M
MIZUUCHI, K
[J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (02) : 771 - 784
[2] BANKIER AT, 1987, METHOD ENZYMOL, V155, P51
[3] SINGLE-STRANDED DEOXYRIBONUCLEIC-ACID NUCLEASE INDUCED BY AFRICAN SWINE FEVER VIRUS AND ASSOCIATED TO THE VIRION
BARROS, MF
CUNHA, CV
COSTA, JV
[J]. VIROLOGY, 1986, 155 (01) : 183 - 191
[4] HUMAN CYTOMEGALO-VIRUS INDUCES EXPRESSION OF CELLULAR TOPOISOMERASE-II
BENSON, JD
HUANG, ES
[J]. JOURNAL OF VIROLOGY, 1990, 64 (01) : 9 - 15
[5] 2 SPECIFIC TOPOISOMERASE-II INHIBITORS PREVENT REPLICATION OF HUMAN CYTOMEGALO-VIRUS DNA - AN IMPLIED ROLE IN REPLICATION OF THE VIRAL GENOME
BENSON, JD
HUANG, ES
[J]. JOURNAL OF VIROLOGY, 1988, 62 (12) : 4797 - 4800
[6] SEDIMENTATION OF AN RNA-POLYMERASE COMPLEX FROM VACCINIA VIRUS THAT SPECIFICALLY INITIATES AND TERMINATES TRANSCRIPTION
BROYLES, SS
MOSS, B
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (01) : 7 - 14
[7] CASEIN KINASE-II PHOSPHORYLATES THE EUKARYOTE-SPECIFIC C-TERMINAL DOMAIN OF TOPOISOMERASE-II INVIVO
CARDENAS, ME
DANG, Q
GLOVER, CVC
GASSER, SM
[J]. EMBO JOURNAL, 1992, 11 (05) : 1785 - 1796
[8] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
DEVEREUX, J
HAEBERLI, P
SMITHIES, O
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (01) : 387 - 395
[9] Dixon L. K., 1990, Molecular Biology of Iridoviruses., P271
[10] IDENTIFICATION OF A VARIABLE REGION OF THE AFRICAN SWINE FEVER VIRUS GENOME THAT HAS UNDERGONE SEPARATE DNA REARRANGEMENTS LEADING TO EXPANSION OF MINISATELLITE-LIKE SEQUENCES
DIXON, LK
BRISTOW, C
WILKINSON, PJ
SUMPTION, KJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 216 (03) : 677 - 688

← 1 2 3 4 5 6 →