AN EXPERIMENTAL-MODEL OF FEMORAL CONDYLAR DEFECT LEADING TO OSTEOARTHROSIS

被引：95

作者：

LEFKOE, TP ^{[1
]}

TRAFTON, PG ^{[1
]}

EHRLICH, MG ^{[1
]}

WALSH, WR ^{[1
]}

DENNEHY, DT ^{[1
]}

BARRACH, HJ ^{[1
]}

AKELMAN, E ^{[1
]}

机构：

[1] BROWN UNIV,RHODE ISL HOSP,SCH MED,DEPT ORTHOPAED,PROVIDENCE,RI 02903

来源：

JOURNAL OF ORTHOPAEDIC TRAUMA | 1993年 / 7卷 / 05期

关键词：

STEP-OFF; ARTICULAR CARTILAGE; INCONGRUITY; OSTEOARTHROSIS; CONDYLAR DEFECT;

D O I：

10.1097/00005131-199310000-00009

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The acute treatment of articular step-off injuries is based largely on reduction criteria, because the presence of residual incongruity has been correlated with the development of posttraumatic arthrosis (PTA). However, this association has not been demonstrated on a prospective basis. Using the rabbit femoral condyle, we developed a surgical model of articular condylar defect without sacrificing the axial alignment or inherent stability of the knee joint. Twenty weeks after the creation of 5-mm femoral condylar defects, progressive osteoarthritic changes were confirmed by radiographic, histological, and biochemical parameters. Osteophytes were observed on the medial aspect of operated knee joints in 67% of cases. Femoral and tibial articular cartilage at the site of the condylar defect exhibited fibrillation, hypocellularity, and severe loss of safranin-O staining. Focal areas of cartilage were denuded or replaced by pannus. In no case was femoral congruity restored by cartilage repair. Statistically significant decreases in proteoglycan content were demonstrated for cartilage sampled from the weight-bearing region of the condylar defect and from the tibial surface directly beneath it. These changes resemble those arising from previously reported models of osteoarthrosis. We present the model as a valid tool for the study of articular condylar defect and its role in the development of PTA.

引用

页码：458 / 467

页数：10

共 29 条

[1]

Altman R., Dean D., Osteoarthritis research: Experimental models, Semin Arthritis Rheum, 19, pp. 21-25, (1990)

[2]

Apley A., Fractures of the tibial plateau, Clin Orthop, 10, pp. 61-74, (1979)

[3]

Ateshian G., Soslowsky L., Human knee joint anatomy and cartilage thickness, Trans Orthop Res Soc, 17, (1992)

[4]

Bitter T., Muir H., A modified uronic acid carbazole reaction, Anal Biochem, 4, pp. 330-334, (1962)

[5]

Brandt K., Braunstein E., Visco D., O'Connor B., Heck D., Albrecht M., Anterior (Cranial) cruciate ligament transection in the dog: A bona fide model of osteoarthritis, not merely of cartilage injury and repair, Trans Orthop Res Soc, 16, (1991)

[6]

Brown T., Erson D., Nepola J., Singerman R., Pedersen D., Brand R., Contact stress aberrations following imprecise reduction of simple tibial plateau fractures, J Orthop Res, 6, pp. 851-862, (1988)

[7]

Convery F., Akeson W., Keown G., The repair of large osteochondral defects: An experimental study in horses, Clin Orthop, 82, pp. 253-262, (1972)

[8]

Ehrlich M., Mankin H., Jones H., Grossman A., Crispen C., Ancona D., Biochemical confirmation of an experimental osteoarthritis model, J Bone Joint Surg [Am], 57, pp. 392-396, (1975)

[9]

Harkess J., Ramsey W., Ahmadi B., Principles of fractures and dislocations, Fractures in Adults, 1, pp. 113-117, (1984)

[10]

Heppenstall R., Radiocarpal and distal radioulnar joints, Fracture Treatment and Healing, pp. 509-513, (1980)

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