COORDINATION BEHAVIOR OF SULFATHIAZOLE - CRYSTAL-STRUCTURE OF DICHLORO-DISULFATHIAZOLE ETHANOL CU(II) COMPLEX - SUPEROXIDE-DISMUTASE ACTIVITY

The crystal structure of [Cu(sulfathiazole)(2)(EtOH)Cl-2] (triclinic; a = 7.82(1), b = 11.441(3), c = 16.606(6) Angstrom A, alpha = 109.68(4), beta = 102.24(4), gamma = 91.27(4)degrees, Z = 2, space group P $($) over bar$$ 1) has been determined from the intensities of 2605 independent reflections (graphite monochromator MoK alpha; 4-circle diffractometer; R = 4.5%). The coordination polyhedron around Cu(II) ion is intermediate between square pyramid and trigonal bipyramid. The spectroscopic data and the rhombic powder EPR spectrum are in agreement with the distorted geometry of the Cu(II) ion. The superoxide dismutase activity of the title compound has been measured and compared with those of the free drug and other sulfathiazole complexes.