EXPRESSION OF THE ARP PROTEIN, A MEMBER OF THE M-PROTEIN FAMILY, IS NOT SUFFICIENT TO INHIBIT PHAGOCYTOSIS OF STREPTOCOCCUS-PYOGENES

被引：70

作者：

HUSMANN, LK

SCOTT, JR

LINDAHL, G

STENBERG, L

机构：

[1] EMORY UNIV,DEPT MICROBIOL & IMMUNOL,ATLANTA,GA 30322

[2] LUND UNIV,DEPT MED MICROBIOL,LUND,SWEDEN

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 01期

关键词：

D O I：

10.1128/IAI.63.1.345-348.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many Streptococcus pyogenes immunoglobulin-binding proteins have structural similarities to the antiphagocytic M protein, including the well-known C repeats. One of these molecules is the immunoglobulin A-binding protein Arp, which is expressed by a serotype 4 strain for which no antiphagocytic M protein has yet been described. We expressed Arp4 in an S. pyogenes strain from which the structural gene for the M protein has been deleted and found that Arp4 is not sufficient to inhibit phagocytosis.

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页码：345 / 348

页数：4

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