ISOLATION AND CHARACTERIZATION OF AN UNUSUAL NUCLEOSIDE, 1-ALPHA-D-RIBOFURANOSYL-4-PYRIDONE-3-CARBOXAMIDE, FROM THE URINES OF NORMAL HUMAN INDIVIDUALS AND LEUKEMIC PATIENTS

被引：6

作者：

CHHEDA, GB

PATRZYC, HB

TWOREK, HA

DUTTA, SP

机构：

[1] Department of Biophysics, Roswell Park Cancer Institute, Buffalo

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 07期

关键词：

D O I：

10.1080/15257779508009489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel modified nucleoside, 1-alpha-D-Ribofuranosyl-4-pyridone-3-carboxamide, has been isolated from the urines of one normal human individual and two CML patients. The structure was assigned on the basis of UV, NMR and mass spectral data and confirmed by comparison with an authentic sample synthesized in our laboratory. This constitutes the first example of the occurrence of a nucleoside with an alpha-riboside linkage in human urine.

引用

页码：1519 / 1537

页数：19

共 37 条

[1]

BERNOFSKY C, 1982, J BIOL CHEM, V257, P6809

[2] DOWEX-1-INDUCED REACTIONS OF REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE (NADH) [J].