NITRIC-OXIDE MODULATES BLOOD-BRAIN-BARRIER PERMEABILITY DURING INFECTIONS WITH AN INACTIVATED BACTERIUM

被引：34

作者：

SHUKLA, A ^{[1
]}

DIKSHIT, M ^{[1
]}

SRIMAL, RC ^{[1
]}

机构：

[1] IND TOXICOL RES CTR,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

NEUROREPORT | 1995年 / 6卷 / 12期

关键词：

BLOOD-BRAIN BARRIER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; N-NITRO-L-ARGININE METHYL ESTER; L-ARGININE; DEXAMETHASONE;

D O I：

10.1097/00001756-199508000-00010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE objective of the present investigation was to study the involvement of NO in regulating the permeability of the blood-brain barrier (BBB) during infections, since NOS is known to be induced following infections. The administration of inactivated Escherichia coli (a source of lipopolysaccharide) or poly (I:C), an interferon inducer, to rats increased the permeability of BBB significantly. This increase was found to be potentiated in the presence of L-arginine, a substrate for NOS, while D-arginine had no such effect. N-nitro L-arginine methyl ester, an inhibitor of NOS, and dexamethasone, an inhibitor of NOS induction, blocked the E. coli-induced effects. These results suggest that during infections, NOS inductions causes the release of large quantities of NO, resulting in increased BBB permeability.

引用

页码：1629 / 1632

页数：4

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