CRIMEAN-CONGO HEMORRHAGIC-FEVER TREATED WITH ORAL RIBAVIRIN

被引:155
作者
FISHERHOCH, SP
KHAN, JA
REHMAN, S
MIRZA, S
KHURSHID, M
MCCORMICK, JB
机构
[1] AGA KHAN UNIV,DEPT COMMUNITY HLTH SCI,KARACHI 748000,PAKISTAN
[2] SANDEMAN HOSP,DEPT SURG,QUETTA,PAKISTAN
来源
LANCET | 1995年 / 346卷 / 8973期
关键词
D O I
10.1016/S0140-6736(95)91323-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Crimean-Congo Haemorrhagic Fever (CCHF) is an often-lethal haemorrhagic fever caused by a tick-borne virus. There are no published data on ribavirin treatment of CCHF-infected patients, despite established in-vitro and in-vivo sensitivity. We report three health workers-two surgeons and a hospital worker-infected with CCHF Virus ill Pakistan who were treated with oral ribavirin 4 g/day for four days, then 2.4 g/day for six days. Intravenous ribavirin was unavailable. All three patients were severely ill with low platelet and white-cell counts, raised aspartate transaminase acid evidence of impaired haemostasis. Based on published reports, all had an estimated probability of death of 90% or more. The patients became afebrile, and their haematological and biochemical abnormalities returned to normal within 48 h of ribavirin treatment; all made a complete recovery, and developed IgG and IgM antibody to CCHF virus. Our experience with ribavirin treatment is encouraging, but does not constitute evidence of efficacy. Given the difficulties in gathering adequate treatment data, we propose a consensus protocol for both intravenous and oral treatment of CCHF. This protocol could be distributed to key medical personnel in areas endemic for CCHF and used to provide a firm basis for effective treatment recommendations.
引用
收藏
页码:472 / 475
页数:4
相关论文
共 25 条
  • [1] ALTIKRITI SK, 1981, B WORLD HEALTH ORGAN, V59, P85
  • [2] NOSOCOMIAL OUTBREAK OF VIRAL HEMORRHAGIC-FEVER CAUSED BY CRIMEAN HEMORRHAGIC-FEVER CONGO VIRUS IN PAKISTAN, JANUARY 1976
    BURNEY, MI
    GHAFOOR, A
    SALEEN, M
    WEBB, PA
    CASALS, J
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1980, 29 (05) : 941 - 947
  • [3] EFFECTS OF RIBAVIRIN ON RED-BLOOD-CELLS
    CANONICO, PG
    KASTELLO, MD
    SPEARS, CT
    BROWN, JR
    JACKSON, EA
    JENKINS, DE
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 74 (02) : 155 - 162
  • [4] RISK-FACTORS FOR CRIMEAN-CONGO HEMORRHAGIC-FEVER IN RURAL NORTHERN SENEGAL
    CHAPMAN, LE
    WILSON, ML
    HALL, DB
    LEGUENNO, B
    DYKSTRA, EA
    BA, K
    FISHERHOCH, SP
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (04) : 686 - 692
  • [5] FISHERHOCH SP, 1985, LANCET, V2, P1227
  • [6] RISK OF HUMAN INFECTIONS WITH CRIMEAN-CONGO HEMORRHAGIC-FEVER VIRUS IN A SOUTH-AFRICAN RURAL-COMMUNITY
    FISHERHOCH, SP
    MCCORMICK, JB
    SWANEPOEL, R
    VANMIDDELKOOP, A
    HARVEY, S
    KUSTNER, HGV
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 47 (03) : 337 - 345
  • [8] PROSPECTIVE, DOUBLE-BLIND, CONCURRENT, PLACEBO-CONTROLLED CLINICAL-TRIAL OF INTRAVENOUS RIBAVIRIN THERAPY OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME
    HUGGINS, JW
    HSIANG, CM
    COSGRIFF, TM
    GUANG, MY
    SMITH, JI
    WU, ZO
    LEDUC, JW
    ZHENG, ZM
    MEEGAN, JM
    WANG, QN
    OLAND, DD
    GUI, XE
    GIBBS, PH
    YUAN, GH
    ZHANG, TM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (06) : 1119 - 1127
  • [9] HUGGINS JW, 1989, REV INFECT DIS, V2, pS750
  • [10] RIBAVIRIN DISPOSITION IN HIGH-RISK PATIENTS FOR ACQUIRED-IMMUNODEFICIENCY-SYNDROME
    LASKIN, OL
    LONGSTRETH, JA
    HART, CC
    SCAVUZZO, D
    KALMAN, CM
    CONNOR, JD
    ROBERTS, RB
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (05) : 546 - 555