SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF POTENT NEW ANGIOTENSIN CONVERTING ENZYME-INHIBITORS CONTAINING SATURATED BICYCLIC AMINO-ACIDS

被引：51

作者：

BLANKLEY, CJ ^{[1
]}

KALTENBRONN, JS ^{[1
]}

DEJOHN, DE ^{[1
]}

WERNER, A ^{[1
]}

BENNETT, LR ^{[1
]}

BOBOWSKI, G ^{[1
]}

KROLLS, U ^{[1
]}

JOHNSON, DR ^{[1
]}

PEARLMAN, WM ^{[1
]}

HOEFLE, ML ^{[1
]}

ESSENBURG, AD ^{[1
]}

COHEN, DM ^{[1
]}

KAPLAN, HR ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PHARMACEUT RES,DEPT PHARMACOL,ANN ARBOR,MI 48105

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 06期

关键词：

D O I：

10.1021/jm00389a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：992 / 998

页数：7

共 28 条

[1] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A KETOMETHYLENE ANALOG OF A TRIPEPTIDE INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME [J].

ALMQUIST, RG ;

CHAO, WR ;

ELLIS, ME ;

JOHNSON, HL .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) :1392-1398

[2]

[Anonymous], 1973, ORG SYNTH COLL

[3]

BAUM T, 1985, NEW DRUGS ANN CARDIO, V3, P43

[4]

BORONDY PE, 1982, PHARMACOLOGIST, V24, P95

[5]

CHEUNG HS, 1980, J BIOL CHEM, V255, P401

[6]

CIGNARELLA G, 1976, GAZZ CHIM ITAL, V106, P65

[7] ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - IMPORTANCE OF THE AMIDE CARBONYL OF MERCAPTOACYL AMINO-ACIDS FOR HYDROGEN-BONDING TO THE ENZYME [J].

CONDON, ME ;

PETRILLO, EW ;

RYONO, DE ;

REID, JA ;

NEUBECK, R ;

PUAR, M ;

HEILKES, JE ;

SABO, EF ;

LOSEE, KA ;

CUSHMAN, DW ;

ONDETTI, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :250-258

[8]

CUSHMAN DW, 1980, PROG MED CHEM, V17, P42

[9] C-aminophthalacone and N-aminophthalimidine [J].

Darapsky, A ;

Heinrichs, P .

JOURNAL FUR PRAKTISCHE CHEMIE-LEIPZIG, 1936, 146 (8/12) :307-318

[10] EFFECTS OF N-MERCAPTOACYLAMINO ACIDS ON INHIBITION OF ANGIOTENSIN-I CONVERTING ENZYME [J].

FUNAE, Y ;

YAMAMOTO, K ;

KOMORI, T ;

SASAKI, D .

JAPANESE JOURNAL OF PHARMACOLOGY, 1978, 28 (06) :925-927

← 1 2 3 →