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PROSTAGLANDIN STIMULATION OF RAT CORTICOSTEROIDOGENESIS

被引：148
作者：
FLACK, JD
JESSUP, R
RAMWELL, PW
机构：
[1] Worster Foundation for Experimental Biology, Shrewsbury, MA
来源：
SCIENCE | 1969年 / 163卷 / 3868期
关键词：
D O I：
10.1126/science.163.3868.691
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Prostaglandins and their C20:ω6 fatty acid precursors are present in rat adrenal glands. Small doses of prostaglandins (PGE1, PGE2, or PGF1α, 1.4 to 2.4 micromolar) increased steroidogenesis in the superfused adrenal glands obtained from hypophysectomized rats. This effect was mimicked in part by both adrenocorticotropin and its postulated intracellular intermediate adenosine 3′,5′-cyclic monophosphate; all three responses were inhibited by cycloheximide.
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页码：691 / &
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