STABILITY OF BETAMETHASONE-17-VALERATE IN SEMISOLID BASES

被引：37

作者：

YIP, YW ^{[1
]}

PO, ALW ^{[1
]}

机构：

[1] UNIV ASTON,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13532.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stability of betamethasone‐17‐valerate in semi‐solid bases has been investigated. Emphasis has been placed on the stability problems which could arise upon dilution of proprietary preparations by the use of model systems. Betamethasone‐17‐valerate has been shown to decompose to betamethasone‐21‐valerate and betamethasone alcohol. Quantitation of the decomposition was by direct densitometry on thin layer chromatographic plates. The decomposition was found to be an apparent first order process and to depend on the diluent used and its concentration. Attempts were also made to relate the rate of decomposition to the pH of the base used, and to stabilize the products. 1979 Royal Pharmaceutical Society of Great Britain

引用

页码：400 / 402

页数：3

共 4 条

[1] COLORIMETRIC DETERMINATION OF BETAMETHASONE BENZOATE IN TOPICAL GEL PREPARATION BY LEWBART-MATTOX METHOD [J].