METABOLISM AND EXCRETION OF NEUROLEPTIC DRUG PIMOZIDE (R-6238) BY WISTAR RAT

被引：15

作者：

SOUDIJN, W

VANWIJNG.I

机构：

[1] Janssen Pharmaceutica, Beerse

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 5P1期

关键词：

D O I：

10.1016/0024-3205(69)90279-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adult male Wistar rats were injected subcutaneously with a 0.31 mg/kg dose of 3H- or 14C-labeled pimozide. The main metabolites identified in the urine were 4-bis (p-flurophenyl)butyric acid, bis (p-fluorophenyl) acetic acid and N-4-piperidyl-2-benzimidazolinone, indicating oxidative N-dealkylation as the major metabolic pathway. Most of the radioactivity was excreted within 48 hr of injection. © 1969.

引用

页码：291 / &

共 7 条

[1] JANSSEN PAJ, 1968, ARZNEI-FORSCHUNG, V18, P282
[2] JANSSEN PAJ, 1968, ARZNEI-FORSCHUNG, V18, P261
[3] JANSSEN PAJ, 1968, ARZNEI-FORSCHUNG, V18, P279
[4] A SIMPLIFIED METHOD OF SAMPLE PREPARATION FOR DETERMINATION OF TRITIUM CARBON-14 OR SULFUR-35 IN BLOOD OF TISSUE BY LIQUID SCINTILLATION COUNTING
MAHIN, DT
LOFBERG, RT
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[5] STERKMANS P, IN PRESS
[6] METABOLISM AND EXCRETION OF BENZETIMIDE HYDROCHLORIDE (R 4929) BY RATS
VANWIJNG.I
SOUDIJN, W
[J]. LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1968, 7 (5P1): : 225 - &
[7] METABOLISM AND EXCRETION OF ANALGESIC FENTANYL (R 4263) BY WISTAR RATS
VANWIJNGAARDEN, I
SOUDIJN, W
[J]. LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1968, 7 (23P1): : 1239 - +

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