SELECTIVE EFFECT OF ETHANOL ON NOREPINEPHRINE-INDUCED AND NICOTINE-INDUCED EMESIS IN CATS

被引：5

作者：

BELESLIN, DB ^{[1
]}

JOVANOVICMICIC, D ^{[1
]}

NIKOLIC, SB ^{[1
]}

SAMARDZIC, R ^{[1
]}

机构：

[1] UNIV BELGRADE, CTR CLIN, INST ONCOL & RADIOL, YU-11000 BELGRADE, YUGOSLAVIA

来源：

ALCOHOL | 1991年 / 8卷 / 06期

关键词：

EMESIS; ETHANOL; NOREPINEPHRINE; NICOTINE; INHIBITION; INTRACEREBROVENTRICULAR INJECTION; AREA POSTREMA; CAT;

D O I：

10.1016/S0741-8329(91)90238-R

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The effect of acute ethanol administration into the cerebral ventricles of the unanesthetized cat upon emesis produced by norepinephrine and nicotine injected similarly was investigated. Ethanol inhibited the norepinephrine- and nicotine-induced emesis. The inhibitory effect of ethanol occurred after a transient and inconsistent emetic action of the drug. Ethanol was about 10 times more potent inhibiting the emesis caused by nicotine. On the other hand, intracerebroventricular ethanol had virtually no effect on emesis produced by intragastric copper sulfate. The inhibitory effect of ethanol is ascribed to an action on alpha-noradrenergic and nicotinic receptors in the area postrema. Differential responses to ethanol most probably reflect the microenvironment of alpha-noradrenergic and nicotinic synapses in the area postrema of the cat.

引用

页码：499 / 501

页数：3

共 20 条

[1] ALTERATIONS IN BETA-ADRENERGIC-RECEPTOR BINDING DURING ETHANOL WITHDRAWAL
BANERJEE, SP
SHARMA, VK
KHANNA, JM
[J]. NATURE, 1978, 276 (5686) : 407 - 409
[2] EMESIS INDUCED BY 4-(M-CHLOROPHENYL-CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE (MCN-A-343) - EVIDENCE FOR A PREDOMINANT CENTRAL MUSCARINIC M1 MEDIATION
BELESLIN, DB
NEDELKOVSKI, V
[J]. NEUROPHARMACOLOGY, 1988, 27 (09) : 949 - 956
[3] NORADRENALINE-INDUCED EMESIS - ALPHA-2 ADRENOCEPTOR MEDIATION IN THE AREA POSTREMA
BELESLIN, DB
STRBAC, M
[J]. NEUROPHARMACOLOGY, 1987, 26 (08) : 1157 - 1165
[4] DIMETHYLPHENYLPIPERAZINIUM-INDUCED VOMITING - NICOTINIC MEDIATION IN AREA POSTREMA
BELESLIN, DB
KRSTIC, SK
[J]. BRAIN RESEARCH BULLETIN, 1986, 16 (01) : 5 - 10
[5] AREA POSTREMA - CHOLINERGIC AND NORADRENERGIC REGULATION OF EMESIS - A NEW CONCEPT
BELESLIN, DB
STRBAC, M
JOVANOVICMICIC, D
SAMARDZIC, R
NEDELKOVSKI, V
[J]. ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1989, 97 (01): : 107 - 115
[6] FURTHER-STUDIES ON NICOTINE-INDUCED EMESIS - NICOTINIC MEDIATION IN AREA POSTREMA
BELESLIN, DB
KRSTIC, SK
[J]. PHYSIOLOGY & BEHAVIOR, 1987, 39 (06) : 681 - 686
[7] CARMICHAEL FJ, 1975, J PHARMACOL EXP THER, V193, P824
[8] D'ACQUISTO R, 1986, Proceedings American Society of Clinical Oncology Annual Meeting, V5, P257
[9] FELBERG W, 1953, J PHYSIOL-LONDON, V120, pP3
[10] HARRIS RA, 1981, MOL PHARMACOL, V20, P128

← 1 2 →