IFOSFAMIDE ALONE AND IN COMBINATION IN THE TREATMENT OF REFRACTORY MALIGNANT GESTATIONAL TROPHOBLASTIC DISEASE

被引：32

作者：

SUTTON, GP

SOPER, JT

BLESSING, JA

HATCH, KD

BARNHILL, DR

机构：

[1] INDIANA UNIV,SCH MED,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SECT,INDIANAPOLIS,IN 46202

[2] DUKE UNIV,MED CTR,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,DURHAM,NC 27710

[3] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,GYNECOL ONCOL GRP,BUFFALO,NY 14263

[4] UNIV ARIZONA,ARIZONA HLTH SCI CTR,COLL MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,TUCSON,AZ 85724

[5] WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1992年 / 167卷 / 02期

关键词：

IFOSFAMIDE; REFRACTORY GESTATIONAL TROPHOBLASTIC DISEASE;

D O I：

10.1016/S0002-9378(11)91435-5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We attempted to evaluate the use of ifosfamide either alone or in combination in patients with refractory malignant gestational trophoblastic disease. STUDY DESIGN: Our study comprised, in part, a phase II multiinstitutional trial of ifosfamide in refractory gynecologic malignancies and, in part, a review of institutional experience with ifosfamide in combination chemotherapy. RESULTS: Single-agent ifosfamide produced a significant response in titer in one of two patients with refractory choriocarcinoma. Ifosfamide with etoposide and cisplatin (also known as VIP) resulted in significant response in human chorionic gonadotropin titers in three patients with highly refractory metastatic gestational trophoblastic disease and one cure in this group of patients. CONCLUSION: Ifosfamide has activity in refractory choriocarcinoma and, when combined with etoposide and cisplatin (VIP), may be curative.

引用

页码：489 / 495

页数：7

共 23 条

[1]

BAGSHAWE KD, 1984, J REPROD MED, V29, P813

[2]

BAGSHAWE KD, 1976, ANN ACADEMY MEDICINE, V5, P273

[3] EMA/CO REGIMEN IN HIGH-RISK GESTATIONAL TROPHOBLASTIC TUMOR (GTT) [J].

BOLIS, G ;

BONAZZI, C ;

LANDONI, F ;

MANGILI, G ;

VERGADORO, F ;

ZANABONI, F ;

MANGIONI, C .

GYNECOLOGIC ONCOLOGY, 1988, 31 (03) :439-444

[4]

CURRY SL, 1989, OBSTET GYNECOL, V73, P357

[5]

DUBESHTER B, 1989, J REPROD MED, V34, P189

[6]

EINHORN LH, 1981, CANCER RES, V41, P3275

[7]

GORDON AN, 1986, CANCER, V58, P1407, DOI 10.1002/1097-0142(19861001)58:7<1407::AID-CNCR2820580704>3.0.CO

[8]

2-2

[9]

HAINSWORTH JD, 1983, CANCER TREAT REP, V67, P393

[10] TREATMENT OF METASTATIC TROPHOBLASTIC DISEASE - GOOD AND POOR PROGNOSIS [J].

HAMMOND, CB ;

BORCHERT, LG ;

TYREY, L ;

CREASMAN, WT ;

PARKER, RT .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1973, 115 (04) :451-457

← 1 2 3 →