SMOOTH-MUSCLE DILATATION IN THE HUMAN UTERINE ARTERY INDUCED BY SUBSTANCE-P, VASOACTIVE INTESTINAL POLYPEPTIDE, CALCITONIN GENE-RELATED PEPTIDE AND ATRIAL-NATRIURETIC-PEPTIDE - RELATION TO ENDOTHELIUM-DERIVED RELAXING SUBSTANCES

被引：29

作者：

BODELSSON, G ^{[1
]}

STJERNQUIST, M ^{[1
]}

机构：

[1] UNIV LUND,GEN HOSP,DEPT OBSTET & GYNAECOL,S-21401 MALMO,SWEDEN

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 09期

关键词：

BIOACTIVE PEPTIDES; ENDOTHELIUM-DERIVED RELAXING FACTOR; NORADRENALINE; ENDOTHELIUM; HUMAN UTERINE ARTERY;

D O I：

10.1093/oxfordjournals.humrep.a137823

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The relaxatory influences of substance P (SP), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) were investigated in human uterine arteries precontracted by noradrenaline in vitro. SP, VIP, CGRP and ANP all relaxed isolated uterine arteries with intact endothelium. When tested on vessels devoid of their endothelium VIP and SP had no effect on smooth muscular tone, while ANP and CGRP still induced unchanged vasodilatation. These results suggest an involvement of an endothelium-derived relaxing substance in the mechanisms by which VIP and SP induce relaxation of the isolated human uterine artery. On the other hand, ANP and CGRP seem to act on the same vessel preparation in vitro independently of the vascular endothelium. Both addition of noradrenaline and exchange of sodium against potassium in the organ chambers resulted in smooth muscle contraction irrespective of the integrity of the endothelium.

引用

页码：1185 / 1188

页数：4

共 17 条

[1] Bodelsson G., Owman C.H., Poulsen H., Sjӧberg N.-O., Stjemquist M., Zia E., Relaxation of the human uterine artery by atrial natriuretic peptide (ANP) is independent of the endothelium, Am. J. Obstet. Gynecol, 165, pp. 483-484, (1991)
[2] Bodelsson M., Ameklo-Nobin B., Tomebrandt K., Cooling augments contractile response to 5-hydroxytryptamine via an endothelium-dependent mechanism, Blood Vessels, 26, pp. 347-359, (1989)
[3] Cheny P.D., Furchgott R.F., Zawadzki J.V., The indirect nature of bradykinin relaxation of isolated arteries: Endothelial dependent and independent components (Abstr), Fed. Prod., 40, (1981)
[4] Edvinsson L., Fredholm B., Hamel E., Jansen I., Verrecchia C., Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat, Neurosci. Lett., 58, pp. 213-217, (1985)
[5] Feletou M., Vanhoutte P.M., Endothelium-derived factor(S) and membrane potential of vascular smooth muscle, Blood Vessels, 23, (1986)
[6] Furchgott R.F., Role of endothelium in responses of vascular smooth muscle, Circ. Res., 35, pp. 557-573, (1983)
[7] Furchgott R.F., Zawadzki J.V., ATP relaxes rabbit aortic smooth muscle by both an indirect action via endothelial cells and a direct action (Abstr.), Pharmacologist, 22, (1980)
[8] Hafferl A., Lehrbuch Der Topographischen Anatomic, (1969)
[9] Hsgeststt E.D., Ersson K.-E., Edvinsson L., Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol, Scantl, 117, pp. 49-61, (1983)
[10] Mikkelsen E.O., Costa G., Nyborg N.C.B., Influence of endothelium on the response to calcium agonists, calcium, potassium and noradrenaline in rat aorta, Pharmacol. Toxicol, 62, pp. 22-28, (1988)

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