THE EXPRESSION OF HISTOCOMPATIBILITY-RELATED LEUKOCYTE ANTIGENS IN THE PATHWAY TO CERVICAL-CARCINOMA

被引:57
作者
HILDERS, CGJM [1 ]
HOUBIERS, JGA [1 ]
KRUL, EJT [1 ]
FLEUREN, GJ [1 ]
机构
[1] LEIDEN UNIV,DEPT SURG,2300 RC LEIDEN,NETHERLANDS
关键词
ALLELE-SPECIFIC LOSS; CERVIX; HLA ANTIGENS;
D O I
10.1093/ajcp/101.1.5
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The major histocompatibility complex probably plays a crucial role in the efficacy of the cellular immune response against virally infected cervical diseases. Therefore, the allele-specific histocompatibility-related leukocyte antigens (HLA) class I and II expression on normal (n = 10), premalignant (n = 25), and malignant cervical tissue (n = 30) was investigated. No alterations in monomorphic or locus/allele-specific HLA class I or II expression were observed in normal and premalignant epithelial tissue. In cervical carcinomas, however, a reduced expression of HLA class I antigens was present in 70% of the cases, comprising a monomorphic class I loss in 20%, and an allele-specific loss in 50% of HLA-A2-, 66% of A3-, 56% of Bw4-, and 37% of Bw6-positive patients. De novo expression of class II antigens was observed in 80% of the cervical carcinomas, with the sublocus products being expressed in the order HLA-DR > HLA-DQ > HLA-DP. The authors' results show that alteration in HLA expression is a process confined to malignant cells, which may allow tumors to evade immune surveillance. In addition, these findings have to be considered as new strategies of immunotherapy using cytotoxic T lymphocytes are developed.
引用
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页码:5 / 12
页数:8
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