A PLASMID MEDIATING PRODUCTION OF A BETA-LACTAMASE BY STENOTROPHOMONAS-MALTOPHILIA

被引：6

作者：

KELLY, MD

MORTENSEN, JE

KONKLE, BA

STULL, TL

机构：

[1] ST CHRISTOPHERS HOSP CHILDREN,DEPT LABS,PHILADELPHIA,PA 19134

[2] THOMAS JEFFERSON UNIV,CARDEZA FDN HEMATOL RES,PHILADELPHIA,PA 19107

[3] TEMPLE UNIV,SCH MED,DEPT PEDIAT,INFECT DIS SECT,PHILADELPHIA,PA

[4] MED COLL PENN,DEPT PEDIAT & MICROBIOL IMMUNOL,PHILADELPHIA,PA

来源：

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1995年 / 56卷 / 02期

关键词：

D O I：

10.1016/0011-393X(95)85040-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To delineate the mechanisms that contribute to the high level of antimicrobial resistance often demonstrated by Stenotrophomonas mat maltophilia, DNA was purified from five clinical isolates and analyzed for the presence of plasmid DNA. Purified plasmid DNA from a single isolate contained a 6.5-kb plasmid, designated pXM222, and a 5.6-kb plasmid, designated pTHB. Transformation of pTMB into Escherichia coli K-12 HB101 resulted in the expression of resistance to the penicillins and to cefazolin.

引用

页码：152 / 162

页数：11

共 17 条

[1] SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS OF MUTANT STRAINS OF XANTHOMONAS-MALTOPHILIA WITH HIGH-LEVEL AND LOW-LEVEL CONSTITUTIVE EXPRESSION OF L1 AND L2 BETA-LACTAMASES [J].