T-CELL ACTIVATION AND THE BALANCE OF ANTIBODY ISOTYPES IN HUMAN LYMPHATIC FILARIASIS

被引：134

作者：

MAIZELS, RM

SARTONO, E

KURNIAWAN, A

PARTONO, F

SELKIRK, ME

YAZDANBAKHSH, M

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT BIOCHEM, LONDON SW7 2BB, ENGLAND

[2] UNIV INDONESIA, FAC MED, DEPT PARASITOL, JAKARTA, INDONESIA

[3] LEIDEN UNIV, DEPT PARASITOL, LEIDEN, NETHERLANDS

来源：

PARASITOLOGY TODAY | 1995年 / 11卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0169-4758(95)80116-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.

引用

收藏

页码：50 / 56

页数：7

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