THE IN-VIVO ANTIVIRAL ACTIVITY OF INTERLEUKIN-12 IS MEDIATED BY GAMMA-INTERFERON

被引：55

作者：

OZMEN, L

AGUET, M

TRINCHIERI, G

GAROTTA, G

机构：

[1] GENENTECH INC,S SAN FRANCISCO,CA 94080

[2] WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 12期

关键词：

D O I：

10.1128/JVI.69.12.8147-8150.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R(0/0) mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-(g)amma.

引用

页码：8147 / 8150

页数：4

共 18 条

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