CONFIRMATORY TESTS FOR DRUGS IN THE WORKPLACE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引:48
作者
GOLDBERGER, BA [1 ]
CONE, EJ [1 ]
机构
[1] NIDA, ADDICT RES CTR, CHEM & DRUG METAB SECT, BALTIMORE, MD 21224 USA
关键词
D O I
10.1016/0021-9673(94)85218-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The Mandatory Guidelines for Federal Workplace Drug Testing Programs require the use of gas chromatography-mass spectrometry (GC-MS) for the confirmation of presumptive positive urine specimens. This review focuses upon GC-MS methods developed specifically for forensic confirmation of amphetamine, methamphetamine, 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THC-acid), benzoylecgonine, morphine, codeine and phencyclidine in urine for purposes of workplace drug testing. In addition, current laboratory issues pertaining to each drug class are reviewed. Generally, drug assays utilized either liquid-liquid or solid-phase extraction methods, derivatization if necessary, and GC-MS detection operating in the selected ion monitoring mode or by full scan acquisition.
引用
收藏
页码:73 / 86
页数:14
相关论文
共 54 条
[1]   RAPID METHOD FOR THE GC MS CONFIRMATION OF 11-NOR-9-CARBOXY-DELTA-9-TETRAHYDROCANNABINOL IN URINE [J].
BAKER, TS ;
HARRY, JV ;
RUSSELL, JW ;
MYERS, RL .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1984, 8 (06) :255-259
[2]   SIMULTANEOUS DETERMINATION OF MONOACETYLMORPHINE, MORPHINE, CODEINE, AND OTHER OPIATES BY GC/MS [J].
BOWIE, LJ ;
KIRKPATRICK, PB .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (06) :326-329
[3]   FREQUENCY OF COCAINE AND PHENCYCLIDINE DETECTION AT A LARGE URBAN PUBLIC TEACHING HOSPITAL [J].
CHAN, KM ;
MATTHEWS, WS ;
SAXENA, S ;
WONG, ET .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1993, 17 (05) :299-303
[4]   COMPARISON OF DERIVATIVES FOR DETERMINATION OF CODEINE AND MORPHINE BY GAS CHROMATOGRAPHY/MASS SPECTROMETRY [J].
CHEN, BH ;
TAYLOR, EH ;
PAPPAS, AA .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1990, 14 (01) :12-17
[5]  
CLOUETTE R, 1993, J ANAL TOXICOL, V17, P1
[6]   PASSIVE INHALATION OF MARIJUANA SMOKE - URINALYSIS AND ROOM AIR LEVELS OF DELTA-9-TETRAHYDROCANNABINOL [J].
CONE, EJ ;
JOHNSON, RE ;
DARWIN, WD ;
YOUSEFNEJAD, D ;
MELL, LD ;
PAUL, BD ;
MITCHELL, J .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1987, 11 (03) :89-96
[7]   MARIJUANA-LACED BROWNIES - BEHAVIORAL-EFFECTS, PHYSIOLOGIC EFFECTS, AND URINALYSIS IN HUMANS FOLLOWING INGESTION [J].
CONE, EJ ;
JOHNSON, RE ;
PAUL, BD ;
MELL, LD ;
MITCHELL, J .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1988, 12 (04) :169-175
[8]  
CONE EJ, 1993, OCT ANN M SOC FOR TO
[9]   QUANTITATION OF METHAMPHETAMINE AND AMPHETAMINE IN URINE BY CAPILLARY GC/MS .2. DERIVATIZATION WITH 4-CARBETHOXYHEXAFLUOROBUTYRYL CHLORIDE [J].
CZARNY, RJ ;
HORNBECK, CL .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (05) :257-262
[10]  
ElSohly M A, 1989, Forensic Sci Rev, V1, P13