LEUKOCYTE-CONNECTIVE TISSUE CELL INTERACTION .2. SPECIFICITY, DURATION, AND MECHANISM OF INTERACTION EFFECTS

被引：46

作者：

CASTOR, CW

YARON, M

机构：

[1] The University of Michigan Medical Center, Ann Arbor, Michigan

[2] University of Michigan Medical Center, Ann Arbor, Michigan

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 04期

关键词：

D O I：

10.1002/art.1780120405

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human fibroblasts grown in vitro as monolayer cultures were “activated” by syngeneic lymphocytes, polymorphonuclear leukocytes, and fibroblasts as well as by allogeneic leukocytes, human embryonic kidney cells, fibroblasts, and thrombocytes. “Activation” was characterized by increased medium acidity, increased glucose uptake, increased lactate formation, and marked stimulation of hyaluronic acid formation. The “activation” process was blocked by preincubation with actinomycin D, but not by incubation with 2,4 dinitrophenol. “Activated” fibroblasts continued to exhibit increased mucopolysaccharide synthesis for 5 to 28 days following a single exposure to stimulatory materials. Copyright © 1969 American College of Rheumatology

引用

页码：374 / &

共 18 条

[1]

Barker SB, 1941, J BIOL CHEM, V138, P535

[2] METABOLISM OF ACID MUCOPOLYSACCHARIDES IN THE SHWARTZMAN PHENOMENON [J].