EVALUATION OF ANTINOCICEPTIVE ACTIVITY USING ELECTRICAL-STIMULATION OF THE TOOTH-PULP IN THE CONSCIOUS DOG

被引：26

作者：

SKINGLE, M ^{[1
]}

TYERS, MB ^{[1
]}

机构：

[1] GLAXO ALLENBURYS RES LTD,DEPT PHARMACOL,WARE SG12 ODJ,HERTFORDSHIRE,ENGLAND

来源：

JOURNAL OF PHARMACOLOGICAL METHODS | 1979年 / 2卷 / 01期

关键词：

Antinociceptive activity; Centrally acting analgesics; Tooth pulp stimulation;

D O I：

10.1016/0160-5402(79)90018-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A method is described for evaluating antinociceptive activity in the conscious dog using electrical stimulation of the tooth pulp. Electrodes are implanted under general anesthesia into the dentine of one or other of the upper canine teeth. Tooth-pulp nociceptive thresholds are determined before and at intervals after drug or placebo administration such that each dog acts as its own control. Tests comparing unknown and reference drugs are carried out blind, using cross-over designed assays. The test provides a sensitive, reproducible, and clinically predictive method for evaluating the antinociceptive activities of opioid agonist and partial-agonist/antagonist analgesics and nonopioid centrally acting analgesics. Peripherally acting analgesics are inactive in this test. © 1979.

引用

页码：71 / 80

页数：10

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