QUANTITATIVE TRACE ANALYSIS OF THALLIUM IN BIOLOGICAL-MATERIAL

被引：19

作者：

ACHENBACH, C

ZISKOVEN, R

KOEHLER, F

BAHR, U

SCHULTEN, HR

机构：

[1] UNIV BONN,INST HUMANGENET,D-5300 BONN 1,FED REP GER

[2] UNIV BONN,INST PHYSIOL 2,D-5300 BONN 1,FED REP GER

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1979年 / 18卷 / 11期

关键词：

D O I：

10.1002/anie.197908821

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pharmacokinetics of the poisonous element thallium have been examined directly by field desorption mass spectrometry from very small tissue samples. After oral administration of 160 mg/kg to mice, concentrations of 10−4 mol/1 were found in organs. While the teratogenic dose 50% is lower than the lethal dose 50% by a factor of 40, some 12.5% of fetal malformations still occur at 1/1000 of the lethal dose. Copyright © 1979 by Verlag Chemie, GmbH, Germany

引用

页码：882 / 883

页数：2

共 11 条

[1]

ACHENBACH C, UNPUBLISHED

[2]

Beckey H. D., 1975, ANGEW CHEM, V87, P425

[3] FIELD DESORPTION MASS-SPECTROMETRY .2. NEW ANALYTICAL METHODS [J].

BECKEY, HD ;

SCHULTEN, HR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1975, 14 (06) :403-415

[4] QUANTITATIVE FIELD DESORPTION MASS-SPECTROMETRY .10. DETERMINATION OF LITHIUM IN MICROLITER AMOUNTS OF HUMAN-BODY FLUIDS AT THERAPEUTIC AND NORMAL LEVELS BY STABLE ISOTOPE DILUTION AND FIELD DESORPTION MASS-SPECTROMETRY [J].

LEHMANN, WD ;

BAHR, U ;

SCHULTEN, HR .

BIOMEDICAL MASS SPECTROMETRY, 1978, 5 (09) :536-539

[5] DETERMINATION OF ALKALI ELEMENTS BY FIELD DESORPTION MASS-SPECTROMETRY [J].

LEHMANN, WD ;

SCHULTEN, HR .

ANALYTICAL CHEMISTRY, 1977, 49 (12) :1744-1746

[6] QUANTITATIVE FIELD DESORPTION MASS-SPECTROMETRY - STABLE ISOTOPE DILUTION AND CATIONIZATION [J].

LEHMANN, WD ;

SCHULTEN, HR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1977, 16 (03) :184-185

[7]

LEHMANN WD, 1977, ANGEW CHEM, V89, P180

[8]

LUND A, 1956, ACTA PHARMACOL TOX, V12, P260

[9]

SCHULTEN HR, 1978, Z NATURFORSCH C, V33, P178

[10]

SCHULTEN HR, 1978, Z NATURFORSCH C, V33, P484

← 1 2 →