TOTAL SYNTHESIS OF 6-EPI-ERYTHRONOLIDE DERIVATIVES

被引：38

作者：

MULZER, J ^{[1
]}

MARESKI, PA ^{[1
]}

BUSCHMANN, J ^{[1
]}

LUGER, P ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST KRISTALLOG,W-1000 BERLIN 33,GERMANY

来源：

SYNTHESIS-STUTTGART | 1992年 / 1-2期

关键词：

D O I：

10.1055/s-1992-34154

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise convergent synthesis of 6-epi-erythronolide B 3,5-acetonide and of (9R)-dihydro-6-epi-erythronolide B from (R)-2,3-O-isopropylideneglyceraldehyde is described. The key step in the synthesis involves the coupling of two aldehydes, comprising the C1-C6 and the C9-C13 portions of the target molecule, across a formal acetylide dianion (= C7-C8 (Scheme 1).

引用

页码：215 / 228

页数：14

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