DYSPLASIA AND CARCINOMA IN LONGSTANDING ULCERATIVE-COLITIS - AN ENDOSCOPIC AND HISTOLOGICAL SURVEILLANCE PROGRAM

被引:81
作者
LEIDENIUS, M
KELLOKUMPU, I
HUSA, A
RIIHELA, M
SIPPONEN, P
机构
[1] UNIV HELSINKI, CENT HOSP, DEPT SURG 4, SF-00100 HELSINKI 10, FINLAND
[2] UNIV HELSINKI, DEPT PATHOL, SF-00100 HELSINKI 10, FINLAND
[3] JORVI HOSP, ESPOO, FINLAND
关键词
D O I
10.1136/gut.32.12.1521
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
From 1976 to 1989 a total of 66 patients with longstanding ulcerative colitis were entered in a colonoscopic surveillance programme in order to detect dysplasia. Thirty patients had extensive or total ulcerative colitis and 36 left sided colitis. The median duration of the disease at the end of the follow up was 15.0 years. Altogether 182 colonoscopies (2.8 per patient), each involving approximately 20 biopsies from different sites of the colon, were performed. In the total or extensive colitis group, five patients had low grade and one patient had high grade dysplasia. In the left sided colitis group, three patients had low grade dysplasia. In three patients low grade dysplasia was detected in a macroscopic lesion or mass of colonic mucosa. Sixty per cent of the dysplasia specimens were from the right colon. The incidence of dysplasia was higher in patients with extensive colitis and increased with the duration of the disease. None of the patients have so far developed colorectal carcinoma. Our results indicate that a colonoscopic surveillance programme is a safe alternative to prophylactic colectomy in longstanding ulcerative colitis.
引用
收藏
页码:1521 / 1525
页数:5
相关论文
共 19 条
  • [1] BLACKSTONE MO, 1981, GASTROENTEROLOGY, V80, P366
  • [2] BRORSTROM O, 1986, GUT, V27, P1408
  • [3] COLON CANCER, DYSPLASIA, AND SURVEILLANCE IN PATIENTS WITH ULCERATIVE-COLITIS - A CRITICAL-REVIEW
    COLLINS, RH
    FELDMAN, M
    FORDTRAN, JS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (26) : 1654 - 1658
  • [4] CANCER RISK AND LIFE EXPECTANCY OF CHILDREN WITH ULCERATIVE COLITIS
    DEVROEDE, GJ
    TAYLOR, WF
    SAUER, WG
    JACKMAN, RJ
    STICKLER, GB
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1971, 285 (01) : 17 - +
  • [5] EDLING N. P. G., 1961, ACTA CHIR SCAND, V121, P299
  • [6] EDWARDS FC, 1964, GUT, V5, P1
  • [7] GREENSTEIN AJ, 1979, GASTROENTEROLOGY, V77, P290
  • [8] COLORECTAL-CANCER IN ULCERATIVE-COLITIS - A COHORT STUDY OF PRIMARY REFERRALS FROM 3 CENTERS
    GYDE, SN
    PRIOR, P
    ALLAN, RN
    STEVENS, A
    JEWELL, DP
    TRUELOVE, SC
    LOFBERG, R
    BROSTROM, O
    HELLERS, G
    [J]. GUT, 1988, 29 (02) : 206 - 217
  • [9] CANCER RISK IN EXTENSIVE ULCERATIVE-COLITIS
    KEWENTER, J
    AHLMAN, H
    HULTEN, L
    [J]. ANNALS OF SURGERY, 1978, 188 (06) : 824 - 828
  • [10] HAZARD RATES FOR DYSPLASIA AND CANCER IN ULCERATIVE-COLITIS - RESULTS FROM A SURVEILLANCE PROGRAM
    LASHNER, BA
    SILVERSTEIN, MD
    HANAUER, SB
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1989, 34 (10) : 1536 - 1541