1,2,4-TRIAZOLO[4,3-C]PYRIMIDINES FROM 4-ACYLHYDRAZINOPYRIMIDINES

被引：7

作者：

COCCO, MT

CONGIU, C

MACCIONI, A

ONNIS, V

机构：

[1] Dipartimento Farmaco Chimico Tecnologico, Università, Cagliari, I-09124

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 05期

关键词：

D O I：

10.1002/jhet.5570290549

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of N1-acetylacetamidrazones 1 with N-[bis(methylthio)methylene]cyanamide (2) at room temperature in the presence of potassium carbonate in dimethyl sulfoxide affords good yields of ethyl 4-acylhydrazino-2-amino-6-methylthio-5-pyrimidine carboxylate 3. By briefly refluxing compounds 3 in dimethyl sulfoxide, 1,2,4-triazolo[4,3-c]pyrimidine derivatives 4 were obtained. When equimolecular amounts of N1-acylacetamidrazones and compounds 2 were refluxed in dimethyl sulfoxide/toluene, compounds 4 were obtained directly.

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页码：1341 / 1347

页数：7

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