RECOMBINANT HEMOGLOBIN IN THE DEVELOPMENT OF RED-BLOOD-CELL SUBSTITUTES

被引：17

作者：

OGDEN, JE

机构：

[1] Delta Biotechnology Ltd., Notingham NG7 1FD, Castle Court. 59, Castle Boulevard

来源：

TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 03期

关键词：

D O I：

10.1016/0167-7799(92)90181-T

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Increasing concern over viral contamination of blood is spurring the development of a blood substitute which can effectively replace the oxygen-carrying capabilities of transfused erythrocytes. Solutions of chemically modified haemoglobin represent one option being evaluated for this role. More recently, recombinant-DNA techniques have enabled production of human haemoglobin in host expression systems, and progress is being made towards the creation of a genetically engineered molecule incorporating the properties required of a blood substitute.

引用

页码：91 / 96

页数：6

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