STRUCTURE OF SERUM RESPONSE FACTOR CORE BOUND TO DNA

被引：304

作者：

PELLEGRINI, L ^{[1
]}

SONG, T ^{[1
]}

RICHMOND, TJ ^{[1
]}

机构：

[1] ETH ZURICH,INST MOLEK BIOL & BIOPHYS,CH-8093 ZURICH,SWITZERLAND

来源：

NATURE | 1995年 / 376卷 / 6540期

关键词：

D O I：

10.1038/376490a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor Interaction are compactly Integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

引用

页码：490 / 498

页数：9

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