INHIBITION OF HUMAN-LEUKOCYTE ELASTASE (HLE) BY NOVEL BICYCLIC BETA-LACTAMS

被引：11

作者：

FARACI, WS ^{[1
]}

BAKKER, AV ^{[1
]}

SPENCER, RW ^{[1
]}

WILLIAMS, RA ^{[1
]}

JASYS, VJ ^{[1
]}

KELLOGG, MS ^{[1
]}

VOLKMANN, RA ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80938-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel (3,2,0) bicyclic beta-lactam sulfenamides and selected carbon isosteres are inhibitors of human leukocyte elastase. The comparative biological activity and hydrolytic stability of these compounds are described.

引用

页码：2271 / 2276

页数：6

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