CLONING OF CDNA FOR HUMAN GRANZYME-3

被引：18

作者：

PRZETAK, MM ^{[1
]}

YOAST, S ^{[1
]}

SCHMIDT, BF ^{[1
]}

机构：

[1] KHEPRI PHARMACEUT INC,S SAN FRANCISCO,CA 94080

来源：

FEBS LETTERS | 1995年 / 364卷 / 03期

关键词：

SERINE PROTEASE; TRYPTASE; GRANZYME; CYTOPLASMIC GRANULE;

D O I：

10.1016/0014-5793(95)00407-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A serine protease gene was cloned from cDNA prepared from tissue isolated from human ascites, The gene codes for a protein of 264 amino acids, identified as human granzyme 3 by the N-terminal amino acid sequence, Granzyme 3 has the expected features of the chymotrypsin family of serine proteases, and is closely related to other human granzymes (40-45% identity). However, the closest granzyme 3 homologue is the recently characterized rat tryptase, RNK-Tryp-2 (75% identity), From Northern blots, granzyme 3 appears to be highly expressed in peripheral blood leukocytes, spleen, thymus, and lung tissues.

引用

页码：268 / 271

页数：4

共 27 条

[1] THE GENES ENCODING NK-CELL GRANULE SERINE PROTEASES, HUMAN TRYPTASE-2 (TRYP2) AND HUMAN GRANZYME-A (HFSP), BOTH MAP TO CHROMOSOME-5Q11-Q12 AND DEFINE A NEW LOCUS FOR CYTOTOXIC LYMPHOCYTE GRANULE TRYPTASES [J].