EFFECT OF DERMAL APPLICATION OF HEXACHLOROCYCLOHEXANE (HCH) ON MALE REPRODUCTIVE-SYSTEM OF RAT

被引：72

作者：

PRASAD, AK ^{[1
]}

PANT, N ^{[1
]}

SRIVASTAVA, SC ^{[1
]}

KUMAR, R ^{[1
]}

SRIVASTAVA, SP ^{[1
]}

机构：

[1] IND TOXICOL RES CTR, LUCKNOW 226001, UTTAR PRADESH, INDIA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1995年 / 14卷 / 06期

关键词：

HEXACHLOROCYCLOHEXANE; REPRODUCTIVE SYSTEM; RAT; TESTES; SPERM;

D O I：

10.1177/096032719501400603

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 The toxic manifestations of dermally applied hexachloracyclohexane (50 mg or 100 mg kg(-1) body weight day(-1), 5 days in a week for 120 days) on testes and sperm of rat have been investigated. 2 The results indicate that exposure of HCH through the dermal route could lead to an alteration in the activities of marker testicular enzymes viz. sorbitol dehydrogenase (SDH), glucose-6-P-dehydrogenase (G6PDH), gamma-glutamyl transpeptidase (gamma-GT) and beta-glucuronidase (beta Gluc.) associated with specific cell types. 3 Significant quantities of HCH and its isomers accumulated in testes as well as sperm of treated rats. 4 HCH exposure also led to a decrease in serum testosterone levels, epididymal sperm count, sperm motility and an increase in the percentage of abnormal sperm. 5 These observations indicate the possibility of adverse effects of HCH on the male reproductive functions of men exposed dermally to this pesticide in industry or during spraying in the field.

引用

页码：484 / 488

页数：5

共 31 条

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