POLY(L-LEUCYL-L-ORNITHYL-L-LEUCINE) AND ITS GUANIDIZATION PRODUCT . SYNTHESIS AND ANTIBACTERIAL ACTIVITY

被引：17

作者：

FRIDKIN, M

FRENKEL, A

ARIELY, S

机构：

[1] Department of Biophysics, Weizmann Institute of Science, Rehovot

来源：

BIOPOLYMERS | 1969年 / 8卷 / 05期

关键词：

D O I：

10.1002/bip.1969.360080508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of poly(L‐leucyl‐L‐ornithyl‐L‐leucine) and of poly(L‐leucyl‐L‐arginyl‐L‐leucine) is reported. The antibacterial action of the two copolymers was checked by growth inhibition experiments on Staphylococcus aureus. The activity was found to be identical with that of a disordered 1:1 copolymer of L‐ornithine and L‐leucine. Conversion of 75% of the ornithine residues to arginine had no effect on the antibacterial activity. Copyright © 1969 John Wiley & Sons, Inc.

引用

页码：661 / &

共 16 条

[1] ANDERSON GW, 1967, J AM CHEM SOC, V89, P7151
[2] SYNTHESIS OF POLY-L-ARGININE
ARIELY, S
WILCHEK, M
PATCHORNIK, A
[J]. BIOPOLYMERS, 1966, 4 (01) : 91 - +
[3] BERGER A, UNPUBLISHED RESULTS
[4] THE ANTIBACTERIAL ACTION OF SOME BASIC AMINO ACID COPOLYMERS
BICHOWSKYSLOMNICKI, L
BERGER, A
KURTZ, J
KATCHALSKI, E
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1956, 65 (01) : 400 - 413
[5] DEBADOV VG, 1961, 5 INT BIOCH C I
[6] FRENKEL A, 1968, ISRAEL J CHEM, V6
[7] FRITZ SJ, 1951, ANAL CHEM, V23, P589
[8] REVERSIBLE MASKING OF AMINO GROUPS IN RIBONUCLEASE AND ITS POSSIBLE USEFULNESS IN SYNTHESIS OF PROTEIN
GOLDBERGER, RF
ANFINSEN, CB
[J]. BIOCHEMISTRY, 1962, 1 (03) : 401 - &
[9] HABEEB AFS, 1960, CAN J BIOCHEM PHYS, V38, P493
[10] ANTIBIOTICALLY ACTIVE AMINO-ACID COPOLYMERS RELATED TO GRAMICIDIN-S
KATCHALSKI, E
BERGER, A
BICHOWSKYSLOMNICKI, L
KURTZ, J
[J]. NATURE, 1955, 176 (4472) : 118 - 119

← 1 2 →